USC (6-3, 5-2 Pac-12, No. 20 CFP) at No. 4 Washington (9-0, 6-0, No. 4 CFP), 7:30 p.m. (FOX)

Line: Washington by 9.

Series record: USC leads 51-29-4.

WHAT'S AT STAKE

Washington's hopes for a spot in the College Football Playoff face potentially three major challenges in the final four weeks of the season, beginning with the surging Trojans. The Huskies are coming off a 66-point outburst against California, led by the six touchdown passes of QB Jake Browning. But USC is rolling, having won five straight behind QB Sam Darnold. The Trojans have scored 40 or more points in four of the last five games.

KEY MATCHUP

Washington WR John Ross vs. USC CB Adoree' Jackson. The fastest wide receiver in the Pac-12 vs. the fastest cornerback in the conference should make for an entertaining individual matchup. Ross is coming off a career day with six catches for 208 yards and three touchdowns as Washington was able to push the ball downfield early against California and opened up opportunities for others. Jackson biggest threat may be in the return game but he's has two interceptions, six passes defensed and 42 total tackles, and has the speed to keep up with Ross.

PLAYERS TO WATCH

USC: RB Ronald Jones II. Over the past three games, Jones has been responsible for the rediscovery of the Trojans run game. Jones rushed for 223 yards two weeks ago against California and followed up with 171 yards and four touchdowns last week against Oregon.

Washington: DE Connor O'Brien. With sack leader Joe Mathis now out for the season due to foot surgery, O'Brien will be responsible for holding the edge in the run game and getting pressure on Darnold. O'Brien has 16 tackles and one sack in the past three games with Mathis out.

FACTS & FIGURES

Washington has not been 9-0 since 1991 when the Huskies went 12-0. ... USC has been shutout just four times since 1976, three of those at Washington. ... Browning has already set a school record with 34 touchdown passes this season. ... USC has at least 500 yards of offense in its last five games.