No. 6 Florida (10-1) at No.10 Florida St (10-1), 3:30 p.m. (ABC)

Line: Florida State by 7.

Series record: Florida leads 33-21-2.

WHAT'S AT STAKE

Oh my, what isn't at stake? Florida sits fourth in the BCS rankings and while it needs help — plenty actually — it isn't totally shut out of the possibly of getting to the national championship game, but must win in Tallahassee to keep alive any far-fetched hopes. The Gators have already defeated SEC rivals Texas A&M, Vanderbilt and Tennessee on the road. Florida State is aching to prove it's more than the beneficiary of a weak schedule. A 49-37 September victory over Clemson is the Seminoles' lone marquee victory. A win would also be Jimbo Fisher's 30th since taking over the program in 2010 from Bobby Bowden.

KEY MATCHUP

Coordinator Mark Stoops' nation's best defense against the somewhat offensively challenged Gators, who also bring one of the nation's top defenses into the game. However, Florida State's offense is one of the country's best with fifth-year senior EJ Manuel at the helm. Manuel has quietly put together a sparkling senior campaign, connecting on 68.8 percent of his passes for 2,785 yards and 21 touchdowns with five interceptions.

PLAYERS TO WATCH

Florida: QB Jeff Driskel returns after missing last week's game with a sprained ankle. The 6-foot-5, 237-pound sophomore has thrown for 1,472 yards and 10 touchdowns and run for another 424 yards and four TDs. If the ankle is still tender Saturday, Driskel could have problems avoiding Florida State's pass rush, which has racked up 28 sacks.

Florida State: DE Cornellius "Tank" Carradine has been virtually unstoppable all season. The 6-5, 265-pound senior moved into a starting job after Brandon Jenkins suffered a season-ending injury in the season opener. Carradine has responded with a team-leading 69 tackles and 10.5 sacks.

FACTS & FIGURES

Florida State won last year 21-7 in Gainesville despite producing only 95 yards total offense ... It's the first time since 2000 that both schools are ranked in the Top 10 nationally when they meet in their annual regular season finale ... Seminoles have won the last two games by a combined 52-14 margin ... Manuel will try to join Florida State's Heisman Trophy winners, Charlie Ward and Chris Weinke, and Chris Rix as the only Seminoles quarterbacks with back-to-back wins over the Gators in the last quarter century ... Florida Heisman winner Tim Tebow was 3-0 in the series .. Florida State's Dustin Hopkins is the NCAA career scoring leader for kickers with 448 points and is just three field goals shy of becoming the all-time leader in that category ... Hopkins and Florida's Caleb Sturgis are finalists for the Lou Groza award, given to the nation's best placekicker ... Fisher and Florida coach Will Muschamp still share ownership of a beach home.

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Missouri (5-6, 2-5 SEC) at No. 9 Texas A&M (9-2, 5-2), 7:10 p.m. (ESPN2)

Line: Texas A&M by 22.

Series Record: Texas A&M leads 7-5.

WHAT'S AT STAKE

Texas A&M is looking for its first 10-win season since 1998 as the two newcomers to the SEC meet. Missouri needs a win to become bowl eligible and extend its winning streak over the Aggies to four games. Redshirt freshman QB Johnny Manziel needs another big performance to help his chances of becoming the first freshman to win the Heisman Trophy.

KEY MATCHUP

Manziel vs. Missouri's defense. Manziel is second in the nation in total offense with 378 yards a game. He is the fifth player and first freshman in FBS history to pass for at least 3,000 yards with at least 1,000 yards rushing in a season, and his 4,161 yards are a school record for total offense in a season. Missouri's defense is seventh in the SEC and is allowing more than 367 yards a game.

PLAYERS TO WATCH

Missouri: QB James Franklin. Missouri trailed 28-17 in the fourth quarter last season against Texas A&M before Franklin led a rally for the 38-31 overtime win. Franklin has thrown for 1,562 yards and 10 touchdowns and ran for 122 yards this season.

Texas A&M: WR Ryan Swope. The senior has 237 catches for 2,962 yards in his career. He leads A&M's receivers with six touchdowns this season, and his 57 catches for 758 yards are second on the team.

FACTS & FIGURES

This will be the third straight year these teams have met in College Station. ... Missouri went 5-3 against Texas A&M during its time in the Big 12. ... Missouri's 15 overtime games since it was added for the 1995 bowl season are the most in the FBS. ... The Aggies have scored first in each of their games this season. ... The Tigers have 34 players from Texas. ... Texas A&M DE Damontre Moore is third in the nation in sacks, fourth in tackles for losses. ... Missouri DE Kony Ealy is second on the team with seven passes broken up. ... Texas A&M freshman Mike Evans has 67 catches for 923 yards and four touchdowns.

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No. 11 Stanford (9-2, 6-2 Pac-12) at No. 15 UCLA (9-2, 6-2), 6:30 p.m. (Fox)

Line: Stanford by 1 1/2.

Series Record: UCLA leads 45-34-3.

WHAT'S AT STAKE

After enormous victories for both teams last week, UCLA and Stanford could be meeting twice in a seven-day span. The Bruins have clinched the Pac-12 South, while the Cardinal can wrap up the North by beating UCLA or if Oregon loses to Oregon State. Unless Stanford loses and Oregon wins, the Bruins and the Cardinal will meet again next Friday to decide the league title.

KEY MATCHUP

Stanford QB Kevin Hogan vs. UCLA LB Anthony Barr. Hogan is making his third consecutive start, all against ranked opponents. He performed admirably against Oregon State and Oregon, but Barr and the Bruins have made life miserable for quarterbacks all year. Barr is fourth in the nation in sacks, and he ended Matt Barkley's regular season with his 12th sack of the year last week.

PLAYERS TO WATCH

Stanford: RB Stepfan Taylor. The senior is 8 yards away from 4,000 for his career, and 42 yards shy of surpassing Darrin Nelson's school record of 4,033. His steady production will be a key to keeping UCLA's offense off the field.

UCLA: TE Joseph Fauria. Stanford is well-known for its towering tight ends, but the 6-foot-7 Fauria can measure up. He leads the Bruins with 10 TD catches as Brett Hundley's biggest target.

FACTS & FIGURES

UCLA is on a five-game winning streak, its longest unbeaten run since 2005. ... Hundley has completed 76 percent of his passes in UCLA's last four games for 1,057 yards and 11 touchdowns with just two interceptions. ... Stanford leads the FBS in rushing defense, while UCLA RB Johnathan Franklin is the school's career rushing leader and a finalist for the Doak Walker Award. ... A win would Stanford three straight 10-win seasons for the first time in school history. ... The Cardinal have won three straight over the Bruins.

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No. 22 Oklahoma State (7-3, 5-2 Big 12) at No. 14 Oklahoma (8-2, 6-1), 3:30 p.m. Saturday (ESPN)

Line: Oklahoma by 7

Series Record: Oklahoma leads 81-18-7

WHAT'S AT STAKE

While trying to stay in position for at least a share of the Big 12 championship, Oklahoma will attempt to regain bragging rights in the Bedlam rivalry. Oklahoma State, which won the outright Big 12 crown after blowing out the Sooners 44-10 last season, also has an outside shot at splitting the conference title.

KEY MATCHUP

Oklahoma State offense vs. Oklahoma defense. The Sooners gave up a school-record 778 yards in a 50-49 victory at West Virginia last week, and the Cowboys rank third in the nation in scoring and total yardage with a similar, Dana Holgorsen-inspired offense.

PLAYERS TO WATCH

Oklahoma State: RB Joseph Randle. Slowed recently by an ankle injury, Randle rushed for 151 yards and two touchdowns against the Sooners last season and can only hope to get close to the 344 yards West Virginia's Tavon Austin racked up against Oklahoma last Saturday.

Oklahoma: QB Landry Jones. Making his final start at home, Jones is coming off a 554-yard outing with six touchdown passes. The yardage broke his own school record, and the TD passes tied his mark. He also directed the Sooners' first fourth-quarter comeback in five years.

FACTS & FIGURES

Coach Mike Gundy has said QB Clint Chelf will make his third career start for Oklahoma State, following back-to-back wins against West Virginia and Texas Tech. ... The Cowboys have scored special teams touchdowns in three straight games. ... WR Kenny Stills tied a school record by catching four of Jones' touchdown passes last week. It was the most ever by a Sooners wide receiver. ... Oklahoma claims 82 victories in the series, including a 1972 win it later forfeited.