No. 16 Colorado (7-2, 5-1 Pac-12, No. 12 CFP) at Arizona (2-7, 0-6), 10 p.m. (Fox Sports 1)

Line: Colorado by 16.

Series Record: Colorado leads 13-5.

WHAT'S AT STAKE

Colorado has set itself up for a showdown with No. 13 Utah for the Pac-12 South title on Nov. 26. To get there the Buffaloes must avoid a letdown against the Wildcats, who will not go to a bowl game for the first time since 2011.

KEY MATCHUP

Arizona's defense against Colorado QB Sefo Liufao. Liufao got banged up against UCLA last week, but facing Arizona's defense could make him feel a whole lot better. The Wildcats 117th nationally in total defense, allowing 475.2 yards per game, and fell into a 24-0 first-quarter hole on their way to a 69-7 loss to No. 25 Washington State last week.

PLAYERS TO WATCH

Colorado: CB Chidobe Awuzie. The versatile senior can play multiple positions and is a disruptive force in blitz packages, holding the CU record for sacks by a defensive back with three. Whichever quarterback starts for Arizona — Anu Solomon or Brandon Dawkins — will need to keep an eye on Awuzie at all times.

Arizona: RB Samajie Grant. With Arizona decimated by injuries in the backfield, Grant switched from receiver to running back to help out. He's arguably Arizona's most explosive offensive player and has handled the position well, all things considered. He rushed for 77 yards on eight carries last week.

FACTS & FIGURES

Colorado had been a combined 0-18 against Arizona State, Oregon, Stanford and UCLA prior to beating all three this season. ... Arizona coach Rich Rodriguez said RB Nick Wilson is likely done for the season after his latest injury. ... Seventeen players have scored points for the Buffaloes this season. ... Arizona has rushed for 1,422 combined yards its last four games against Colorado.