Missouri quarterback Kelly Bryant (7) celebrates with teammates after a touchdown during the third quarter of an NCAA college football game against Mississippi, Saturday, Oct. 12, 2019, in Columbia, Mo. (AP Photo/L.G. Patterson)
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No. 22 Missouri (5-1, 2-0 SEC) at Vanderbilt (1-5, 0-3), Saturday at 4 p.m. EDT (SEC Network).

Line: Missouri by 20 1/2.

Series record: Missouri 7-3-1.

WHAT'S AT STAKE?

Missouri can show they play as well on the road as at home coming off a five-game home stand. A win keeps them atop the SEC East. Vanderbilt desperately needs a win over an SEC opponent after a stunning home loss to UNLV a week ago.

KEY MATCHUP

Missouri's very stingy defense against Vanderbilt's struggling offense. The Tigers rank sixth nationally in yards allowed and have allowed opponents to get inside their 20 just 12 times this season, the fewest in the SEC this season. Vanderbilt opened its quarterback competition after a 34-10 loss to UNLV.

PLAYERS TO WATCH

Missouri: QB Kelly Bryant. The senior threw for 329 yards and a TD in the Tigers' last game, and he is averaging 262.5 yards passing this season. He ranks 28th nationally with 12 TD passes.

Vanderbilt: RB Ke'Shawn Vaughn. He is coming off his best game this season with 140 yards rushing on just 15 carries in the loss to UNLV, and he also had a 53-yard reception.

FACTS & FIGURES

Missouri is off to its best start since winning its first seven to open the 2013 season. The Tigers finished 12-2 in 2013 and won the SEC East. ... Missouri off to best SEC start since going 3-0 in 2013. ... Missouri has won three straight and five of last seven in this series. ... Missouri is coming off a five-game home stand and now will play three straight on the road. ... Missouri has scored 31 or more points in 11 straight games, second-longest streak in nation only to Oklahoma (16). ... Missouri has scored six defensive TDs, most in nation this season. ... Vanderbilt and Missouri are among only four Power 5 teams with 2,000-yard career rusher and 2,000-yard career receiver. ... Vaughn ranks fourth in SEC averaging 101.2 yard rushing per game. ... Vanderbilt QB Riley Neal ranks fourth nationally with 8,495 career yards passing.

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